Structure of PDB 5y3k Chain B Binding Site BS01

Receptor Information
>5y3k Chain B (length=750) Species: 9796 (Equus caballus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLPPFLPCELQPHGLVNCNWLFLKSVPHFSAAAPRDNVTSLSLLSNRIHH
LHDSDFAQLSNLQKLNLKWNCPPAGLSPMHFPCHMTIEPNTFLAVPTLEE
LNLSYNGITTVPALPSSLVSLILSRTNILQLDPTSLTGLHALRFLYMDGN
CYYKNPCGRALEVAPGALLGLGNLTHLSLKYNNLTTVPRSLPPSLEYLLL
SYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCVECPHKFPQLHS
DTFSHLSRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFLYDCITKT
KAFQGLAQLRRLNLSFNYHKKVSFAHLTLAPSFGSLLSLQELDMHGIFFR
SLSQKTLQPLARLPMLQRLYLQMNFINQAQLGIFKDFPGLRYIDLSDNRI
SGAVESEDFMPSCKNLSFTLDLSRNNLVTVQPEMFAQLSRLQCLRLSHNS
ISQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTELPRLEALDLSYNSQ
PFSMRGVGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQLCSTSLWALDFSG
NSLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGNLPKSLQL
LRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLD
VSRNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDV
SANPLHCACGAAFVDFLLQVQAAVPGLPSRVKCGSPGQLQGRSIFAQDLR
Ligand information
Receptor-Ligand Complex Structure
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PDB5y3k Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation
Resolution2.7 Å
Binding residue
(original residue number in PDB)		W47 F49 K51 S72 R74 W96 P99 S104 P105 M106 F108 S131 Y132 S151 R152 Y173 D175 K207
Binding residue
(residue number reindexed from 1)		W20 F22 K24 S45 R47 W69 P72 S77 P78 M79 F81 S104 Y105 S124 R125 Y146 D148 K180
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5y3k, PDBe:5y3k, PDBj:5y3k
PDBsum5y3k
PubMed29625894
UniProtQ2EEY0|TLR9_HORSE Toll-like receptor 9 (Gene Name=TLR9)

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