Structure of PDB 5xyi Chain B Binding Site BS01

Receptor Information
>5xyi Chain B (length=219) Species: 5722 (Trichomonas vaginalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFIKKEWRHVMPAYFTGKHDIGVTVSNKCARGRVPMDYVNNRVWELSHAD
MVNDLSHAYRLFSWRSIAAGSEVYTQFAGMRLTHDKLDSIMRKYRTLINA
SVDAKTADGFILRLFTVGFTKKLANSHKNHTYANSHKARQVRDVMVKCLT
DACESNGVEQLCKDFVDEKIENEIVEKCKQICQIEGVYITKVKVIKAPAL
SNEQVKVLKISKDAAQLSL
Ligand information
>5xyi Chain 2 (length=1490) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acuugguugauccugccaaggaagcacacuuaggucauagauuaagccau
gcaaguguuaguaacugcgaauagcucauuaauacgcucagaaucuauuu
ggcggggauagcagcagcaacucuggugcuaauacaugcuguuucuccag
augugaauuauggaggaaaaguugaccucgaggcacgccauucgacugag
ugaccuaucagcuuguacuuagggucuuuaccuagguaggcuaucacggg
uaacgggcgguuaccgucggacugccggagaaggcgccugagagauagcg
acuauauccacggguagcagcaggcgcgaaacuuucccacucgagacuuu
cggaggagguaaugaccaguuccauugguuacguggauagggguacgguu
uuccaccguaccgacuagcagagggcagucuggugccagcagcugcggua
auuccagcucugcgaguuugcucccauauuguugcaguuaaaacgcccgu
agucugaauuggccagcaauggucguacguauacguucacugugaacaau
caggacgcuuagaguauggccacaugaaugacucagcgcaguaugaaguc
uuuguuaaaacaagcucaaugagagccaucggggguagaucuaucucaug
acgagugguggaauacuuugacucaugagagagaagcugaggcgaaggcg
ucuaccuagaggguuucugucgaucaagggcgagaguaggaguauccaac
aggauuagagacccugguaguuccuaccuuaaacgaugccgacaggaguu
ugucauuuguuaauggcagaaucuuuggagaaaucauaguucuugggcuc
ugggggaaauacgaccgcaaggcugaaacuugaaggaauugacggaaggg
cacaccagggguggagccuguggcuuaauuugaaucaacacggggaaacu
acccaggaccagauguuuaugacugacaggcuucgggucuuucaggauau
uguuuuugguggugcauggccguugguggugcguggguugaccuguccgu
ugauucagcuaacgagcgagauuaucgccaauuauuuacuuugccgaagu
ccuucgguuaaaguucuaauugggacucccugcguagcagguggaagagg
guagcaauaacagguccgugaugcccuuuagaugcucugggcugcacgcg
ugcuacaauguuaggacaauaggagcgagccugagagggugcgcuacucu
uauaaucccuaacguaguugggauugacguuuguaaucagcgucaugaac
caggaaucccuuguaaaugugugucaacaacgcacguugaauacgucccu
gcccuuuguacacaccgcccgucgcuccuaccgauuggaugacucgguga
aaucaccggauggaaagugauuaaaucacguuaucuagaggaaggagaag
ucguaacaagguaacgguaggugaaccugccguuggauca
..<<<<<.[.((((>>>>><<.<<<<.<<...<<<<<<<......<<<.<
<<..<<....<<.>>.>>......<<........<<<<<<...<<....<
<<<<..<...<<<.<<.......>>.>>>.....>......<<<<<<<<.
..<.....>.>>>>>>>>.......<<<..>>>..>>>>>...>>.>>>>
>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>
...<<<.<<<<....>>>>.....>>>.>>.<<.<<<..........>>>
.>>.<<<<....>>>>...>>>>>>.........<<<....<<<<...>>
>>..>>>..>>.>>>>>...<<<<.<<....>>>>>>....<<<<<<<<.
....>>>>>>>>.....<<<<<((...<.<<<<.....<<..))>>....
...>>>>>>>>>>..>>.>>>>.>>.........<<<((.....<<<<..
.<<<.<<...<<<<......>>>>....<<..>>.<<<<<<<<<.....<
<<..<<.......>><<<....>>>...>>>.....>>>>>..>>>>...
...<<....>>....>>....<<<<<<.<...<<<<<<<<<..<<<<<<<
<...<<<......>>>......>>>>>>>>..>>.......<<....>>.
>>>>>>>...>>>>.>>>...>>>...>>>>..<.<<<<<<<...<...<
<<<.<.....>.>>>>...>>>>>>>>..>.......<<<.<<.<<<.<<
<<<<<<<....>>>>>>>>>.>>>...<<..))>>...>>.....>>>.>
>>.<<<......<.<<....>>.>....>>>..)))).]<<<<<.<<<<<
<<.<<..<<<<<..<<<.<<<<<<......<<........>>........
.<<<<<<...............<<<<.<<<.......>>>.>>>>.....
.......<<.<<<..<<.<<<<<<....<<.<<<<<<....>>>..<.<.
.....>.>...>>>.>>....<<<<<.<<<<<<<...<<<<<<<<<<<..
..>>>>>>.>>>>>..>>>>>>>.....<<<<<...>>>>>........>
>>>>....>>>.>>>.....>>>>>>>........>>>>>>..>>.>>>>
.>>>.....<<<<<<.....<<<.<<..<<<<....>>>>..>>....>>
>......>>>>>>...........<<<<<<<.......>>>>>>>.....
.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>
>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<..<<<..
<<<<<<..........>>>>>>..>>>..>>>>>>>...>>.>>>>>..>
.>>...>.....<<<<<<<<<....>>>>>>>>>......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5xyi Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Resolution3.35 Å
Binding residue
(original residue number in PDB)		K23 N60 V62 R84 M110 R111 K112 Y113 R132 F134 N144 S145 K147 H149 Y151 N153 S154 R158 R161 I200 K212
Binding residue
(residue number reindexed from 1)		K5 N41 V43 R65 M91 R92 K93 Y94 R113 F115 N125 S126 K128 H130 Y132 N134 S135 R139 R142 I181 K193
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5xyi, PDBe:5xyi, PDBj:5xyi
PDBsum5xyi
PubMed28809395
UniProtA2G9Z8

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