Structure of PDB 5xwm Chain B Binding Site BS01

Receptor Information
>5xwm Chain B (length=354) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EITSLDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEF
PNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSV
KALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFE
RVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTN
FDVTYNWIQDKCVPLVREITFENGEELTEEGLPFLILFHMKEDTESLEIF
QNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHM
YVFGDFKDVLIPGKLKQFVFDLHSGKLHREFHHGPDPTASSPPESSFQKL
APSE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5xwm Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5xwm Zinc regulates ERp44-dependent protein quality control in the early secretory pathway.
Resolution2.45 Å
Binding residue
(original residue number in PDB)		H277 H281
Binding residue
(residue number reindexed from 1)		H277 H281
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003756 protein disulfide isomerase activity
GO:0005515 protein binding
Biological Process
GO:0006457 protein folding
GO:0006986 response to unfolded protein
GO:0009100 glycoprotein metabolic process
GO:0034976 response to endoplasmic reticulum stress
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0009986 cell surface
GO:0035580 specific granule lumen
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xwm, PDBe:5xwm, PDBj:5xwm
PDBsum5xwm
PubMed30723194
UniProtQ9BS26|ERP44_HUMAN Endoplasmic reticulum resident protein 44 (Gene Name=ERP44)

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