Structure of PDB 5xou Chain B Binding Site BS01

Receptor Information
>5xou Chain B (length=574) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRA
GGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDP
GERSVLSALARRLLQERLRRLEGVWVEGLAVYRREGWRVLGGAVLDLWVS
DSGAFLLEVDPAYRILCLSLPWEERRRRTREIASWIGRRLGLGTPEAVRA
QAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFL
RRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTP
PMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQ
VVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAG
ERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRNGRVPQDEFALALEAL
AREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFR
GTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADR
LVKEVGRLGIRHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
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PDB5xou Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Resolution2.63 Å
Binding residue
(original residue number in PDB)		A170 R172 I173 R286 M413 W415 K422 Q433 I434 N436 R446 N449 E512 R513 P550 Q551 R580 R611 T613 P614 R615 A644 S645 P650 R651 H657 R661 V685
Binding residue
(residue number reindexed from 1)		A162 R164 I165 R175 M302 W304 K311 Q322 I323 N325 R335 N338 E401 R402 P439 Q440 R469 R500 T502 P503 R504 A533 S534 P539 R540 H546 R550 V574
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:5xou, PDBe:5xou, PDBj:5xou
PDBsum5xou
PubMed28911094
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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