Structure of PDB 5x71 Chain B Binding Site BS01

Receptor Information
>5x71 Chain B (length=795) Species: 142805 (Rice dwarf virus (isolate O)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DYCIPNFSQTVNERTIIDIFTICRYRSPLVVFCLSHNELAKKYAQDVSMS
SGTHVHIIDGSVEITVSLYRTFRTIATQLLGRMQIVVFVTVDKSVVSTQV
MKSIAWAFRGSFVELRNQSVDSSTLVSKLENLVSFAPLYNVPKCGPDYYG
PTVYSELLSLATNARTHWYATIDYSMFTRSVLTGFVAKYFNEEAVPIDKR
IVSIVGYNPPYVWTCLRHGIRPTYIEKSLPNPGGKGPFGLILPVINELVL
KVKYVMHNPQIKLLCLDTFMLSTSMNILYIGAYPATHLLSLQLNGWTILA
FDPKITSDWTDAMAKATGAKVIGVSKEFDFKSFSVQANQLNMFQNSKLSV
IDDTWVETDYEKFQSEKQAYFEWLIDRTSIDVRLISMKWNRSKDTSVSHL
LALLPQPYGASIREMRAFFHKKGASDIKILAAETEKYMDDFTAMSVSDQI
NTQKFMHCMITTVGDALKMDLDGGRAVIASYSLSNSSNSKERVLKFLSDA
NKAKAMVVFGAPNTHRLAYAKKVGLVLDSAIKMSKDLITFSNPTGRRWRD
YGYSQSELYDAGYVEITIDQMVAYSSDVYNGVGYFANSTYNDLFSWYIPK
WYVHKRMLMQDIRLSPAALVKCFTTLIRNICYVPHETYYRFRGILVDKYL
RSKNVDPSQYSIVGSGSKTFTVLSHFEVPHECGPLVFEASTDVNISGHLL
SLAIAAHFVASPMILWAEQMKYMAVDRMLPPNLDKSLFFDNKVTPSGALQ
RWHSREEVLLAAEICESYAAMMLNNKHSPDIIGTLKSAINLVFKI
Ligand information
Ligand ID5GP
InChIInChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyRQFCJASXJCIDSX-UUOKFMHZSA-N
SMILES
SoftwareSMILES
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=C1c2ncn(c2N=C(N)N1)C3OC(C(O)C3O)COP(=O)(O)O
OpenEye OEToolkits 1.5.0c1nc2c(n1C3C(C(C(O3)COP(=O)(O)O)O)O)N=C(NC2=O)N
OpenEye OEToolkits 1.5.0c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H14 N5 O8 P
NameGUANOSINE-5'-MONOPHOSPHATE
ChEMBLCHEMBL283807
DrugBankDB01972
ZINCZINC000002159505
PDB chain5x71 Chain B Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5x71 Crystal structure of the capping enzyme P5 from Rice Dwarf Virus
Resolution2.568 Å
Binding residue
(original residue number in PDB)		Q616 P622 S702 G703 H704 W722 N747 W758 H759
Binding residue
(residue number reindexed from 1)		Q610 P616 S696 G697 H698 W716 N741 W752 H753
Annotation score3
Enzymatic activity
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004484 mRNA guanylyltransferase activity
GO:0005525 GTP binding
GO:0016779 nucleotidyltransferase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5x71, PDBe:5x71, PDBj:5x71
PDBsum5x71
PubMed
UniProtP14583|MCE_RDVA Putative mRNA-capping enzyme P5

[Back to BioLiP]