Structure of PDB 5w9a Chain B Binding Site BS01

Receptor Information
>5w9a Chain B (length=191) Species: 9544 (Macaca mulatta) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DHCARHGEKLLLFCQEDSKVICWLCKDSQEHRGHHTFLMEEVAQEYHVKL
QTALEMLRQKQQEAEKLEADIREEKASWKIQIDYDKTNVSADFEQLREIL
DWEESNELQNLEKEEEDILKSLTKSETEMVQQTQYMRELISELEHRLQGS
MMDLLQGVDGIIKRIENMTLKKPKTFHKNQRRVAPDLKGML
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5w9a Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5w9a A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5 alpha and mammalian autophagy-related ATG8 proteins.
Resolution2.74 Å
Binding residue
(original residue number in PDB)		C97 H100 C116
Binding residue
(residue number reindexed from 1)		C3 H6 C22
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5w9a, PDBe:5w9a, PDBj:5w9a
PDBsum5w9a
PubMed30282803
UniProtQ0PF16|TRIM5_MACMU Tripartite motif-containing protein 5 (Gene Name=TRIM5)

[Back to BioLiP]