Structure of PDB 5vy9 Chain B Binding Site BS01

Receptor Information
>5vy9 Chain B (length=849) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QFTERALTILTLAQKLASDHQHPQLQPIHILAAFIETPEDGSVPYLQNLI
EKGRYDYDLFKKVVNRNLVRIPQQQPAPAEITPSYALGKVLQDAAKIQKQ
QKDSFIAQDHILFALFNDSSIQQIFKEAQVDIEAIKQQALELRGYLSKYA
IDMTEQARQGKLDPVIGREEEIRSTIRVLARRIKSNPCLIGEPGIGKTAI
IEGVAQRIIDDDVPTILQGAKLFSLDLAALTAGAKYKGDFEERFKGVLKE
IEESKTLIVLFIDEIHMLMGNGKDDAANILKPALSRGQLKVIGATTNNEY
RSIVEKDGAFERRFQKIEVAEPSVRQTVAILRGLQPKYEIHHGVRILDSA
LVTAAQLAKRYLPYRRLPDSALDLVDISCAGVAVARDSKPEELDSKERQL
QLIQVEIKALERDEDADSTTKDRLKLARQKEASLQEELEPLRQRYNEEKH
GHEELTQAKKKLDELENKALDAERRYDTATAADLRYFAIPDIKKQIEKLE
DQVAEEERRAGANSMIQNVVDSDTISETAARLTGIPVKKLSESENEKLIH
MERDLSSEVVGQMDAIKAVSNAVRLSRSGLANPRQPASFLFLGLSGSGKT
ELAKKVAGFLFNDEDMMIRVDCSELSEKYAVSKLLGTTAGYVGYDEGGFL
TNQLQYKPYSVLLFDEVEKAHPDVLTVMLQMLDDGRITSGQGKTIDCSNC
IVIMTSNLGAEFINSQQGSKIQESTKNLVMGAVRQHFRPEFLNRISSIVI
FNKLSRKAIHKIVDIRLKEIEERFEQNDKHYKLNLTQEAKDFLAKYGYSD
DMGARPLNRLIQNEILNKLALRILKNEIKDKETVNVVLEECLEVLPNHE
Ligand information
>5vy9 Chain P (length=28) Species: 9913 (Bos taurus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AAAAAAAAAAAAAAAAAAAAAAAAAAAA
Receptor-Ligand Complex Structure
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PDB5vy9 Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.
Resolution6.7 Å
Binding residue
(original residue number in PDB)		Y257 G661 V663
Binding residue
(residue number reindexed from 1)		Y236 G640 V642
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0051082 unfolded protein binding
GO:0051087 protein-folding chaperone binding
Biological Process
GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane
GO:0034605 cellular response to heat
GO:0034975 protein folding in endoplasmic reticulum
GO:0035617 stress granule disassembly
GO:0042026 protein refolding
GO:0043335 protein unfolding
GO:0051085 chaperone cofactor-dependent protein refolding
GO:0070370 cellular heat acclimation
GO:0070414 trehalose metabolism in response to heat stress
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0034399 nuclear periphery
GO:0072380 TRC complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5vy9, PDBe:5vy9, PDBj:5vy9
PDBsum5vy9
PubMed28619716
UniProtP31539|HS104_YEAST Heat shock protein 104 (Gene Name=HSP104)

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