Structure of PDB 5vxz Chain B Binding Site BS01

Receptor Information
>5vxz Chain B (length=376) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDP
EGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQ
TISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHE
KDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFY
PGSGFAFYSLDYMTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALV
DQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEV
SAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVN
RRLLDLDEAAYKHSDITAHSCPPVEP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5vxz Chain B Residue 703 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5vxz Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D329 E331 R440 D656
Binding residue
(residue number reindexed from 1)		D49 E51 R160 D357
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:5vxz, PDBe:5vxz, PDBj:5vxz
PDBsum5vxz
PubMed27893463
UniProtQ14393|GAS6_HUMAN Growth arrest-specific protein 6 (Gene Name=GAS6)

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