Structure of PDB 5vqi Chain B Binding Site BS01

Receptor Information

>5vqi Chain B (length=421) Species: 5141 (Neurospora crassa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DLPKMVEGVFSSEIDKQIQATTKFRKLLSKERNPPIEEVIKTGVVGRFVE
FLRSPHTLVQFEAAWALTNIASGSATQTQVVIEAGAVPIFVELLGSPEPD
VREQAVWALGNIAGDSPQCRDYVLSCGALRPLLTLLGDSRKLSMLRNATW
TLSNFCRGKTPQPDWNTIAPALPVLAKLVYSLDDEVLIDACWAISYLSDG
SNDKIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVTGDDVQTQVI
INCGALPCLLSLLSSNKDGIRKEACWTISNITAGNSAQIQSVIDANIIPP
LIHLLSHADLKTRKEACWAISNATSGGLQKPDQIRYLVAQGCIKPLCDLL
ACPDNKIIQVALDGLENILKVGELDKNAASINRYALFIEECGGMEKIHDC
QTNANEEIYMKAYNIIEKYFS

Ligand information

>5vqi Chain A (length=7) Species: 5141 (Neurospora crassa) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

SSKRQRR

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5vqi Nuclear transport of the Neurospora crassa NIT-2 transcription factor is mediated by importin-alpha.
Resolution	2.501 Å
Binding residue (original residue number in PDB)	S110 K111 F142 W146 N150 A152 S153 Q185 W188 N192 G195 D196 W231 N235
Binding residue (residue number reindexed from 1)	S29 K30 F61 W65 N69 A71 S72 Q104 W107 N111 G114 D115 W150 N154

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Biological Process

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Cellular Component

External links

PDB	RCSB:5vqi, PDBe:5vqi, PDBj:5vqi
PDBsum	5vqi
PubMed	29054975
UniProt	Q9C2K9

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