Structure of PDB 5vpy Chain B Binding Site BS01

Receptor Information
>5vpy Chain B (length=156) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMTEYKLVVVGAAGVGKSALTIQLIQNHFVDEYDDSYRKQVVIDGETCLL
DILDTDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVL
VGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREI
RKHKEK
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5vpy Chain B Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5vpy Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		S17 D57
Binding residue
(residue number reindexed from 1)		S18 D54
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5vpy, PDBe:5vpy, PDBj:5vpy
PDBsum5vpy
PubMed29199977
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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