Structure of PDB 5vem Chain B Binding Site BS01

Receptor Information
>5vem Chain B (length=383) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHHKLPDQQKVLLVSFDGFRWDYLYKVPTPHFHYIMKYGVHVKQVTNVF
ITKTYPNHYTLVTGLFAENHGIVANDMFDPIRNKSFSLDHMNIYDSKFWE
EATPIWITNQRAGHTSGAAMWPGTDVKIHKRFPTHYMPYNESVSFEDRVA
KIIEWFTSKEPINLGLLYWEDPDDMGHHLGPDSPLMGPVISDIDKKLGYL
IQMLKKAKLWNTLNLIITSDHGMTQCSEERLIELDQYLDKDHYTLIDQSP
VAAILPKEGKFDEVYEALTHAHPNLTVYKKEDVPERWHYKYNSRIQPIIA
VADEGWHILQNKSDDFLLGNHGYDNALADMHPIFLAHGPAFRKNFSKEAM
NSTDLYPLLCHLLNITAMPHNGSFWNVQDLLNS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5vem Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5vem A key tyrosine substitution restricts nucleotide hydrolysis by the ectoenzyme NPP5.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		D36 T72 D238 H239
Binding residue
(residue number reindexed from 1)		D18 T54 D220 H221
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0000210 NAD+ diphosphatase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0007154 cell communication
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5vem, PDBe:5vem, PDBj:5vem
PDBsum5vem
PubMed28898552
UniProtQ9UJA9|ENPP5_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (Gene Name=ENPP5)

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