Structure of PDB 5v7g Chain B Binding Site BS01

Receptor Information
>5v7g Chain B (length=317) Species: 266834 (Sinorhizobium meliloti 1021) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPRILVPGKINPRVLERLPEMFETVRIERADAALVTADMRDVSGIAVSGK
LPVPLMDAFPSLEIVANFGVGYDGVDVSRAAARGIVVTNTPDVLTEEVAD
TAIGLLLNTLRLLPQAEQWLRQGRWVREGAFPLSPLSLRGRTVGLFGLGR
IGLAIARRLEAFGVSIAYHTRTPREGLGFTYHPTLVGMAEAVDTLIVIVP
GTASTLKAVNADVLSALGPKGVLINVGRGSTVDEAALVTALQNGTIAGAG
LDVFENEPNVPEALLSFPNVSLLPHVASASVVTRNAMSDLVVDNLKAWFS
TGEALTPVAETPFRRRA
Ligand information
Ligand IDOXL
InChIInChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2
InChIKeyMUBZPKHOEPUJKR-UHFFFAOYSA-L
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341		[O-]C(=O)C([O-])=O
OpenEye OEToolkits 1.5.0C(=O)(C(=O)[O-])[O-]
FormulaC2 O4
NameOXALATE ION
ChEMBL
DrugBank
ZINC
PDB chain5v7g Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5v7g Structural, Biochemical, and Evolutionary Characterizations of Glyoxylate/Hydroxypyruvate Reductases Show Their Division into Two Distinct Subfamilies.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		G71 V72 G73 R230 H277
Binding residue
(residue number reindexed from 1)		G69 V70 G71 R228 H275
Annotation score2
Enzymatic activity
Catalytic site (original residue number in PDB) L96 R230 D254 E259 H277
Catalytic site (residue number reindexed from 1) L94 R228 D252 E257 H275
Enzyme Commision number 1.1.1.81: hydroxypyruvate reductase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016618 hydroxypyruvate reductase [NAD(P)H] activity
GO:0030267 glyoxylate reductase (NADPH) activity
GO:0046872 metal ion binding
GO:0051287 NAD binding
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:5v7g, PDBe:5v7g, PDBj:5v7g
PDBsum5v7g
PubMed29309127
UniProtQ92LZ4

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