Structure of PDB 5v4b Chain B Binding Site BS01
Receptor Information
>5v4b Chain B (length=444) Species:
9606
(Homo sapiens) [
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TQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWR
ILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRID
TNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGK
CLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTS
TVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGR
RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTS
IRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQ
CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT
LESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDM
Ligand information
>5v4b Chain C (length=10) Species:
9606
(Homo sapiens) [
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PEVPPTPPGS
Receptor-Ligand Complex Structure
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PDB
5v4b
FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system.
Resolution
2.6 Å
Binding residue
(original residue number in PDB)
W2425 S2462 R2465 R2479 Y2519 A2626
Binding residue
(residue number reindexed from 1)
W163 S200 R203 R217 Y257 A364
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:5v4b
,
PDBe:5v4b
,
PDBj:5v4b
PDBsum
5v4b
PubMed
28727686
UniProt
Q969H0
|FBXW7_HUMAN F-box/WD repeat-containing protein 7 (Gene Name=FBXW7)
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