Structure of PDB 5uw5 Chain B Binding Site BS01

Receptor Information

>5uw5 Chain B (length=705) Species: 39387 (Gypsophila vaccaria)

ATSGFSKPLHYPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDN
QEKLANSVLEECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQ
AQNVFQMQDDLDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSG
LTEWVTIKILKTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPPAVNQ
EARYHFLGTDQSEDILLWRDLENPAHHLKCQITDDGKYFLLYILDGCDDA
NKVYCLDLTKLPNGLESAPFMKLIDSFDASYTAIANDGSVFTFQTNKDAP
RKKLVRVDLNNPSVWTDLVPESKKDLLESAHAVNENQLILRYLSDVKHVL
EIRDLESGALQHRLPIDIGSVDGITARRRDSVVFFKFTSILTPGIVYQCD
LKNDPTQLKIFRESVVPDFDRSEFEVKQVFVPSKDGTKIPIFIAARKGIS
LDGSHPCEMHGYGGFGINMMPTFSASRIVFLKHLGGVFCLANIRGGGEYG
EEWHKAGFRDKKQNVFDDFISAAEYLISSGYTKARRVAIEGGSNGGLLVA
ACINQRPDLFGCAEANCGVMDMLRFHKFTLGYLWTGDYGCSDKEEEFKWL
IKYSPIHNVRRPWEQPGNEETQYPATMILTADHDDRVVPLHSFKLLATMQ
HVLCTSLEDSPQKNPIIARIQRKAAAYGRATMTQIAEVADRYGFMAKALE
APWID

Ligand information

>5uw5 Chain F (length=6) Species: 39387 (Gypsophila vaccaria)

NASAPV

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5uw5 Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants.
• Resolution: 2.94 Å
• Binding residue (original residue number in PDB): R81 F95 N104 L132 F492 S493 A494 S495 T700
• Binding residue (residue number reindexed from 1): R80 F94 N103 L131 F473 S474 A475 S476 T681

Enzymatic activity

• Catalytic site (original residue number in PDB): A695
• Catalytic site (residue number reindexed from 1): A676
• Enzyme Commision number: 3.4.21.-
  3.4.21.26: prolyl oligopeptidase.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0046872 metal ion binding
• GO:0070012 oligopeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5uw5, PDBe:5uw5, PDBj:5uw5
• PDBsum: 5uw5
• PubMed: 28584123
• UniProt: R4P353