Structure of PDB 5uw3 Chain B Binding Site BS01

Receptor Information

>5uw3 Chain B (length=707) Species: 39387 (Gypsophila vaccaria)

MATSGFSKPLHYPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVD
NQEKLANSVLEECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGL
QAQNVFQMQDDLDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHS
GLTEWVTIKILKTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPPAVN
QEARYHFLGTDQSEDILLWRDLENPAHHLKCQITDDGKYFLLYILDGCDD
ANKVYCLDLTKLPNGLESSAPFMKLIDSFDASYTAIANDGSVFTFQTNKD
APRKKLVRVDLNNPSVWTDLVPESKKDLLESAHAVNENQLILRYLSDVKH
VLEIRDLESGALQHRLPIDIGSVDGITARRRDSVVFFKFTSILTPGIVYQ
CDLKNDPTQLKIFRESVVPDFDRSEFEVKQVFVPSKDGTKIPIFIAARKG
ISLDGSHPCEMHGYGGFGINMMPTFSASRIVFLKHLGGVFCLANIRGGGE
YGEEWHKAGFRDKKQNVFDDFISAAEYLISSGYTKARRVAIEGGSNGGLL
VAACINQRPDLFGCAEANCGVMDMLRFHKFTLGYLWTGDYGCSDKEEEFK
WLIKYSPIHNVRRPWEQPGNEETQYPATMILTADHDDRVVPLHSFKLLAT
MQHVLCTSLEDSPQKNPIIARIQRKAAHYGRATMTQIAEVADRYGFMAKA
LEAPWID

Ligand information

>5uw3 Chain F (length=6) Species: 39387 (Gypsophila vaccaria)

NASAPV

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5uw3 Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants.
• Resolution: 1.96 Å
• Binding residue (original residue number in PDB): R81 F95 A102 N104 L132 F492 S493 A494 S495 T700 I704
• Binding residue (residue number reindexed from 1): R81 F95 A102 N104 L132 F475 S476 A477 S478 T683 I687

Enzymatic activity

• Catalytic site (original residue number in PDB): H695
• Catalytic site (residue number reindexed from 1): H678
• Enzyme Commision number: 3.4.21.-
  3.4.21.26: prolyl oligopeptidase.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0046872 metal ion binding
• GO:0070012 oligopeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5uw3, PDBe:5uw3, PDBj:5uw3
• PDBsum: 5uw3
• PubMed: 28584123
• UniProt: R4P353