Structure of PDB 5uow Chain B Binding Site BS01

Receptor Information
>5uow Chain B (length=795) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FPVLNIAVILGRTRYITERDIRSLWTRDMSLDFDVNVVTLLVQQTDPKSI
ITHVCDLMSGTKIHGVVFGDDTDQEAIAQILDFVSSQTFIPILGIHGGSS
MIMADKDEMSTFFQFGASIKQQATVMLNIMEEYDWHVFSVITSNFPGYRD
FISFIKTTVDNSFVGWEVQNYITLDTSYTDAQTLTQLKKIHSSVILLYCS
KDEATYIFEEARSLGLMGYGFVWIVPSLVTGNTDIIPYEFPSGLVSVSYD
DWDYGIEARVRDGLGIITTAASAMLEKHSVIPEAKTSCYGQNERNDPPLH
TLHNFMINVTWDGKDLSFTEDGYQANPKLVVLLLNMEREWEKVGKWEAKS
LNMKYPVWPRIDSDHDDNHLSIVTLEEAPFVIVENIDYLTGTCVRNTVPC
RKYFRLANSTTEGTSVKKCCKGFCIDILKKLSKTVKFTYDLYLVTNGKHG
KKIKNVWNGMIGEVVYKRAVMAVGSLTINEERSVAVDFSVPFVETGISVM
VSRSAGTVSPSAFLEPFSASVWVMMFVMLLLVSAMAVFIFEYFSPVHGPS
FTIGKAVWLLWGLVFNNSLPVQNPKGTTSKIIVSIWAFFAVIFLASYTAN
LAAFMIQRRFVDQVTGLSDNKFQRPHDYSPPFRFGTVPQGSTERNIRNNY
PDMHQYMVKFHQKGVQDALVSLKTGKLDAFIYDAAVLNYMAGRDEGCKLV
TIGSGYIFATTGYGIALQKGSRWKRPIDLALLQFVGDGEMEELEKLWLTG
ICHTEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFVWEHLFYK
Ligand information
Ligand IDGLU
InChIInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKeyWHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370N[CH](CCC(O)=O)C(O)=O
FormulaC5 H9 N O4
NameGLUTAMIC ACID
ChEMBLCHEMBL575060
DrugBankDB00142
ZINCZINC000001482113
PDB chain5uow Chain B Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5uow Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		H473 T501 G676 S677 T678 D719
Binding residue
(residue number reindexed from 1)		H449 T477 G640 S641 T642 D683
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uow, PDBe:5uow, PDBj:5uow
PDBsum5uow
PubMed28232581
UniProtB7ZSK1|NMDE1_XENLA Glutamate receptor ionotropic, NMDA 2A (Gene Name=grin2a)

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