Structure of PDB 5uan Chain B Binding Site BS01

Receptor Information
>5uan Chain B (length=308) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVT
RNRCQYCRLQKCFEVGMSKESVRTAELDDLTEKIRKAHQETFPSLCQLGK
YTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQ
ITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD
LVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLE
ALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMP
PLIQEMLE
Ligand information
Receptor-Ligand Complex Structure
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PDB5uan The quaternary architecture of RAR beta-RXR alpha heterodimer facilitates domain-domain signal transmission.
Resolution3.508 Å
Binding residue
(original residue number in PDB)		V233 K237 I247 I251 L402 E405
Binding residue
(residue number reindexed from 1)		V133 K137 I147 I151 L302 E305
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0048384 retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uan, PDBe:5uan, PDBj:5uan
PDBsum5uan
PubMed29021580
UniProtP10826|RARB_HUMAN Retinoic acid receptor beta (Gene Name=RARB)

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