Structure of PDB 5u62 Chain B Binding Site BS01

Receptor Information
>5u62 Chain B (length=354) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQ
GEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPIT
MQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIF
GGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD
YNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIV
CWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLAL
GNQVGKLYVWDLEVCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWR
WDRL
Ligand information
>5u62 Chain D (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MFSSNRQKILERTEILNQEWKQRRIQPV
Receptor-Ligand Complex Structure
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PDB5u62 Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		W103 H104 S105 Y154 S159 P161 R201 L246 L315 G316 D317 L318 L353 F372 W373 Q374 R420
Binding residue
(residue number reindexed from 1)		W24 H25 S26 Y75 S80 P82 R122 L167 L236 G237 D238 L239 L274 F293 W294 Q295 R334
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:5u62, PDBe:5u62, PDBj:5u62
PDBsum5u62
PubMed27992714
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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