Structure of PDB 5txr Chain B Binding Site BS01

Receptor Information
>5txr Chain B (length=476) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTV
WCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAEL
ATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIK
HANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKI
CDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTND
KGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTT
TLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPS
HIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPG
HTNDLSDILINAVDDVFNELQLPRVRDWESQGGLLGVVEESNLWTSSQLS
LTNDDLNPNVRDPIVKQLEVSSGIKQ
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain5txr Chain B Residue 605 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5txr Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		C182 Y183 H209 E252 D281 V283 H284 T334 K337
Binding residue
(residue number reindexed from 1)		C115 Y116 H142 E185 D214 V216 H217 T267 K270
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.37: 5-aminolevulinate synthase.
Gene Ontology
Molecular Function
GO:0003870 5-aminolevulinate synthase activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0009058 biosynthetic process
GO:0033014 tetrapyrrole biosynthetic process
GO:1902117 positive regulation of organelle assembly
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5txr, PDBe:5txr, PDBj:5txr
PDBsum5txr
PubMed29551290
UniProtP09950|HEM1_YEAST 5-aminolevulinate synthase, mitochondrial (Gene Name=HEM1)

[Back to BioLiP]