Structure of PDB 5tl6 Chain B Binding Site BS01
Receptor Information
>5tl6 Chain B (length=315) [
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EVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNH
EGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGG
LTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCAL
ILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLT
GVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAE
YKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPV
TDVFYKETSYTTTIK
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
5tl6 Chain B Residue 401 [
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Receptor-Ligand Complex Structure
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PDB
5tl6
Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species.
Resolution
2.618 Å
Binding residue
(original residue number in PDB)
C190 C193 C227
Binding residue
(residue number reindexed from 1)
C189 C192 C226
Annotation score
1
Enzymatic activity
Enzyme Commision number
2.1.1.-
2.1.1.56
: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57
: methyltransferase cap1.
2.7.7.48
: RNA-directed RNA polymerase.
2.7.7.50
: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12
: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69
: SARS coronavirus main proteinase.
3.6.4.12
: DNA helicase.
3.6.4.13
: RNA helicase.
4.6.1.-
Gene Ontology
Molecular Function
GO:0008234
cysteine-type peptidase activity
Biological Process
GO:0006508
proteolysis
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Molecular Function
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Biological Process
External links
PDB
RCSB:5tl6
,
PDBe:5tl6
,
PDBj:5tl6
PDBsum
5tl6
PubMed
28438633
UniProt
P0C6X7
|R1AB_SARS Replicase polyprotein 1ab (Gene Name=rep)
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