Structure of PDB 5t9j Chain B Binding Site BS01

Receptor Information
>5t9j Chain B (length=391) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVNDLWQILEPVKQHIPLRNLGGKTIAVNLSLWVCEAQTVKKMMGSVMKP
HLRNLFFRISYLTQMDVKLVFVMEGEPPKLRYGSSGKSWSQKTGRSHFKS
VLRECLHMLECLGIPWVQAAGEAEAMCAYLNAGGHVDGCLTNDGDTFLYG
AQTVYRNFTMNTKDPHVDCYTMSSIKSKLGLDRDALVGLAILLGCDYLPK
GVPGVGKEQALKLIQILKGQSLLQRFNRWNQLNEVENNIKKKACCCEGFP
FHEVIQEFLLNKDKLVKVIRYQRPDLLLFQRFTLEKMEWPNHYACEKLLV
LLTHYDMIERKLGSRNSNQLQPIRIVKTRIRNGVHCFEIEWEKPEHYAME
DKQHGEFALLTIEEESLFEAAYPEIVAVYQKQKLEIKGKKQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5t9j Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage.
Resolution3.00013 Å
Binding residue
(original residue number in PDB)		K43 R54 N55 F58 R59 M172 Y370 K374
Binding residue
(residue number reindexed from 1)		K42 R53 N54 F57 R58 M160 Y293 K297
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity

View graph for
Molecular Function
External links
PDB RCSB:5t9j, PDBe:5t9j, PDBj:5t9j
PDBsum5t9j
PubMed26682650
UniProtQ17RS7|GEN_HUMAN Flap endonuclease GEN homolog 1 (Gene Name=GEN1)

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