Structure of PDB 5t7l Chain B Binding Site BS01

Receptor Information
>5t7l Chain B (length=75) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKL
QTPKTLQEAIDDMGFDAVIHNIEGR
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain5t7l Chain A Residue 104 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5t7l Mechanistic and Structural Basis for Inhibition of Copper Trafficking by Platinum Anticancer Drugs.
Resolution2.83 Å
Binding residue
(original residue number in PDB)		T14 C15 C18
Binding residue
(residue number reindexed from 1)		T12 C13 C16
Annotation score1
Enzymatic activity
Enzyme Commision number 7.2.2.8: P-type Cu(+) transporter.
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5t7l, PDBe:5t7l, PDBj:5t7l
PDBsum5t7l
PubMed31283225
UniProtQ04656|ATP7A_HUMAN Copper-transporting ATPase 1 (Gene Name=ATP7A)

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