Structure of PDB 5ol0 Chain B Binding Site BS01

Receptor Information
>5ol0 Chain B (length=263) Species: 5671 (Leishmania infantum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APHQEHVLGEPTLEGLAHYIREKNVRRILVLVGAGASVAAGIPDFTDAFS
LTLLREKPEIFYSIARELNLWPGHFQPTAVHHFIRLLQDEGRLLRCCTQN
IDGLEKAAGVSPELLVEAHGSFAAAACIECHTPFSIEQNYLEAMSGTVSR
CSTCGGIVKPNVVFFGENLPDAFFDALHHDAPIAELVIIIGTSMQVHPFA
LLPCVVPKSVPRVVMNRERVGGLLFRFVCRDVLFRGDCQENVVTLAEYLG
LSEALAKRMRLSD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ol0 The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design.
Resolution1.99 Å
Binding residue
(original residue number in PDB)		V188 F190 G191 E192 N193 L194 D196 F199 H222 P223
Binding residue
(residue number reindexed from 1)		V163 F165 G166 E167 N168 L169 D171 F174 H197 P198
Enzymatic activity
Catalytic site (original residue number in PDB) P49 D50 F51 N125 D127 H144
Catalytic site (residue number reindexed from 1) P43 D44 F45 N100 D102 H119
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:5ol0, PDBe:5ol0, PDBj:5ol0
PDBsum5ol0
PubMed29543820
UniProtA0A6L0XH39

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