Structure of PDB 5oki Chain B Binding Site BS01

Receptor Information

>5oki Chain B (length=468) Species: 559292 (Saccharomyces cerevisiae S288C)

SNNYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRV
GWLTNMHATLVSQETLSSGRVTTNQGISGVDFYFLDEEGGSFKSTVVYDP
YFFIACNDESRVNDVEELVKKYLESCLKSLQIIRKEDLNHLLGLQKTLIK
LSFVNSNQLFEARKLLRPILQDNANNNVQRHLIEDIREYDVPYHVRVSID
KDIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFAIATTKPPLKFPDSAVD
QIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEV
ALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAP
DAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDP
ELMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDE
TLRKGTGTLCEMLLMVQA

Ligand information

>5oki Chain I (length=26) Species: 559292 (Saccharomyces cerevisiae S288C)

TVKIWVKYNEGFSNAVRKNVTWNNLW

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5oki Structural Basis for the Recruitment of Ctf18-RFC to the Replisome.
• Resolution: 4.5 Å
• Binding residue (original residue number in PDB): N389 K392 G395 D400
• Binding residue (residue number reindexed from 1): N333 K336 G339 D344

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.
  3.1.11.-

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity

Biological Process

• GO:0006260 DNA replication
• GO:0006281 DNA repair

Cellular Component

• GO:0008622 epsilon DNA polymerase complex

External links

• PDB: RCSB:5oki, PDBe:5oki, PDBj:5oki
• PDBsum: 5oki
• PubMed: 29225079
• UniProt: P21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)