Structure of PDB 5ok6 Chain B Binding Site BS01

Receptor Information
>5ok6 Chain B (length=217) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELPGLDSQWRQIENGESGRERPLRAGESWFLVEKHWYKQWEAYVQGGDQD
SSTFPGCINNATLFQDEINWRLKEGLVEGEDYVLLPAAAWHYLVSWYGLE
HGQPPIERKVIELPNIQKVEVYPVELLLVRHNDLGKSHTVQFSHTDSIGL
VLRTARERFLVEPQEDTRLWAKNSEGSLDRLYDTHITVLDAALETGQLII
METRKKDGTWPSAQLEH
Ligand information
>5ok6 Chain C (length=14) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AEGEFYKLKIRTPR
Receptor-Ligand Complex Structure
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PDB5ok6 Discovery of peptide ligands targeting a specific ubiquitin-like domain-binding site in the deubiquitinase USP11.
Resolution1.3 Å
Binding residue
(original residue number in PDB)		H161 N162 L164 W200 N203 S207 L208 D209 L245 E246 H247
Binding residue
(residue number reindexed from 1)		H131 N132 L134 W170 N173 S177 L178 D179 L215 E216 H217
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity

View graph for
Molecular Function
External links
PDB RCSB:5ok6, PDBe:5ok6, PDBj:5ok6
PDBsum5ok6
PubMed30373771
UniProtP51784|UBP11_HUMAN Ubiquitin carboxyl-terminal hydrolase 11 (Gene Name=USP11)

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