Structure of PDB 5oi0 Chain B Binding Site BS01

Receptor Information
>5oi0 Chain B (length=445) Species: 1122247 (Mycolicibacterium hassiacum DSM 44199) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PHDPSFTPTQLAARAAYLLRGNDLGTMTTAAPLLYPHMWSWDAAFVAIGL
APLSVERAVVELDTLLSAQWRNGMIPHIVFANGVDGYFPGPARWATATLA
DNAPRNRLTSGITQPPVHAIAVQRILEHARTRGRSTRAVAEAFLDRRWGD
LMRWHRWLAECRDRNERGRITLYHGWESGMDNSPRWDSAYANVVPGKLPE
YQRADNVIITDPSQRPSDGEYDRYLWLLEEMKAVRYDDERLPSVMSFQVE
DVFFSAIFSVACQVLAEIGEDYKRPHADVKDLYLWAERFRAGVVETTDQR
TGAARDFDVLAEKWLVTETAAQFAPLLCGGLPHDRERALLKLLEGPRFCG
HPDLKYGLIPSTSPVSRDFRPREYWRGPVWPVLTWLFSWCFARRGWAERA
RLLRQEGLRQASDGSFAEYYEPFTGEPLGSMQQSWTAAAVLDWLG
Ligand information
Ligand IDSER
InChIInChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKeyMTCFGRXMJLQNBG-REOHCLBHSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CO)C(O)=O
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)O
CACTVS 3.341N[C@@H](CO)C(O)=O
ACDLabs 10.04O=C(O)C(N)CO
OpenEye OEToolkits 1.5.0C([C@@H](C(=O)O)N)O
FormulaC3 H7 N O3
NameSERINE
ChEMBLCHEMBL11298
DrugBankDB00133
ZINCZINC000000895034
PDB chain5oi0 Chain B Residue 505 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5oi0 The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation.
Resolution1.68 Å
Binding residue
(original residue number in PDB)		Y36 Y88 W177 D182
Binding residue
(residue number reindexed from 1)		Y35 Y87 W176 D181
Annotation score2
Enzymatic activity
Enzyme Commision number 3.2.1.208: glucosylglycerate hydrolase.
Gene Ontology
Molecular Function
GO:0004573 Glc3Man9GlcNAc2 oligosaccharide glucosidase activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0102547 glucosylglycerate hydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006487 protein N-linked glycosylation
GO:0009311 oligosaccharide metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5oi0, PDBe:5oi0, PDBj:5oi0
PDBsum5oi0
PubMed31316802
UniProtK5BDL0|GGH_MYCHD Glucosylglycerate hydrolase (Gene Name=ggh)

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