Structure of PDB 5o5z Chain B Binding Site BS01

Receptor Information
>5o5z Chain B (length=449) Species: 2265 (Thermococcus litoralis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESLKDRIRLWKRLYVNAFENALNAIPNVKGVLLAYNTNIDAIKYLDADDL
EKRVTEKGKEKVFEIIENPPEKISSIEELLGGILRSIKLGKAMEWFVESE
EVRRYLREWGWDELRIGGQAGIMANLLGGVYRIPTIVHVPQNPKLQAELF
VDGPIYVPVFEGNKLKLVHPKDAIAEEEELIHYIYEFPRGFQVFDVQAPR
ENRFIANADDYNARVYMRREFREGFEEITRNVELAIISGLQVLKEYYPDG
TTYKDVLDRVESHLNILNRYNVKSHFEFAYTANRRVREALVELLPKFTSV
GLNEVELASIMEIIGDEELAKEVLEGHIFSVIDAMNVLMDETGIERIHFH
TYGYYLALTQGGGRQLAFVPTKIVASPKSTVGIGDTISSSAFVSEFGGGG
GVRDALLFASLAAAAKAMKGNLERIEQIRDALSVPTNERAIVLEEELEK
Ligand information
Ligand IDGLC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL423707
DrugBank
ZINCZINC000003861213
PDB chain5o5z Chain B Residue 505 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5o5z Protein topology determines substrate-binding mechanism in homologous enzymes.
Resolution2.441 Å
Binding residue
(original residue number in PDB)		D42 E96 H184 D387
Binding residue
(residue number reindexed from 1)		D40 E94 H182 D385
Annotation score5
Enzymatic activity
Enzyme Commision number 2.7.1.-
2.7.1.147: ADP-specific glucose/glucosamine kinase.
Gene Ontology
Molecular Function
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5o5z, PDBe:5o5z, PDBj:5o5z
PDBsum5o5z
PubMed30251675
UniProtQ7M537|GLKA_THELN ADP-dependent glucose/glucosamine kinase (Gene Name=glkA)

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