Structure of PDB 5o1m Chain B Binding Site BS01

Receptor Information
>5o1m Chain B (length=371) Species: 256642 (Streptomyces sp. K30) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLWTWSPSASVAGTGVGVDPEYVWDEEADPVLAAVIDRGEVPAVNALLKQ
WTRNDQALPGGLPGDLREFMEHARRMPSWADKAALDRGAQFSKTKGIYVG
ALYGLGSGLMSTAIPRESRAVYYSKGGADMKDRIAKTARLGYDIGDLDAY
LPHGSMIVTAVKTRMVHAAVRHLLPQSPAWSQTSGGQKIPISQADIMVTW
HSLATFVMRKMKQWGVRVNTADAEAYLHVWQVSAHMLGVSDEYIPATWDA
ANAQSKQVLDPILAHTPEGEALTEVLLGIVAELDAGLTRPLIGAFSRYTL
GGEVGDMIGLAKQPVLERLIATAWPLLVAFREGLIPLPAVPAVLWTLEEA
LRKFVLLFLSEGRRIAIDIPD
Ligand information
Ligand IDHEM
InChIInChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;
InChIKeyKABFMIBPWCXCRK-RGGAHWMASA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6Cc1c2n3c(c1CCC(=O)O)C=C4C(=C(C5=[N]4[Fe]36[N]7=C(C=C8N6C(=C5)C(=C8C)C=C)C(=C(C7=C2)C)C=C)C)CCC(=O)O
CACTVS 3.385CC1=C(CCC(O)=O)C2=Cc3n4[Fe]5|6|N2=C1C=c7n5c(=CC8=N|6C(=Cc4c(C)c3CCC(O)=O)C(=C8C=C)C)c(C)c7C=C
ACDLabs 12.01C=1c3c(c(c4C=C5C(=C(C=6C=C7C(=C(C8=CC=2C(=C(C=1N=2[Fe](n34)(N5=6)N78)CCC(=O)O)C)\C=C)C)\C=C)C)C)CCC(=O)O
FormulaC34 H32 Fe N4 O4
NamePROTOPORPHYRIN IX CONTAINING FE;
HEME
ChEMBL
DrugBankDB18267
ZINC
PDB chain5o1m Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5o1m Structural and Functional Analysis of Latex Clearing Protein (Lcp) Provides Insight into the Enzymatic Cleavage of Rubber.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		E148 A151 S155 G158 A159 R164 K167 L171 T194 V197 H198 V201 T230
Binding residue
(residue number reindexed from 1)		E117 A120 S124 G127 A128 R133 K136 L140 T163 V166 H167 V170 T199
Annotation score4
Enzymatic activity
Enzyme Commision number 1.13.-.-
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0008300 isoprenoid catabolic process
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5o1m, PDBe:5o1m, PDBj:5o1m
PDBsum5o1m
PubMed28733658
UniProtQ3L8N0|LCP_STRK3 Rubber oxygenase (Gene Name=lcp)

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