Structure of PDB 5ntg Chain B Binding Site BS01

Receptor Information
>5ntg Chain B (length=510) Species: 5693 (Trypanosoma cruzi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GASEFVRSCVNFETNVEFTDVDAYKKTHTAGLASTFVVILGTHAQLREDA
LKELPFYCPAVAEAIQRVKKGETYAVLAEGVKNEANERFVRVLVGEVPSE
ASRTNCPARPDVVASLLSAALEEIKGPETKVDVFVRSTAALAIAVAAARS
AKRNFTAKEGLATRGYCDNCVRLTVVFPTAPNPSPSELAVVATSTQLCQR
LVDAPTNLLNTATFAEVAQSYAKELGCAVDVICGEELRERGYGGIYSVGK
CAVEAPRLVTLSYKPKDETRKKVALVGKGIVYDSGGLSLKPTNFMTGMKR
DMGGAAAVFCGFLTAVRLQMPIELSCTLCLAENAIGPDAYRNDDILTLKS
GKTVEVNNTDAEGRLVLGDGVFHATHEISFKPDVLVDMATLTGAQGIATG
HRHAGIFVNDEEEELSFLKAGRASGETCFPVLYCPEYHVTEFRSPVADMR
NSVKQVNNASVSCAGQFVANHLSPDFKGKHIHVDMAFPAFENDKATGFGP
ALLTEYLRNL
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain5ntg Chain B Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5ntg Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation inTrypanosoma brucei.
Resolution2.32 Å
Binding residue
(original residue number in PDB)		D293 K300 D370 E372
Binding residue
(residue number reindexed from 1)		D283 K290 D360 E362
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) K300 R374
Catalytic site (residue number reindexed from 1) K290 R364
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008233 peptidase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5ntg, PDBe:5ntg, PDBj:5ntg
PDBsum5ntg
PubMed28815215
UniProtV5BWE3

[Back to BioLiP]