Structure of PDB 5nj7 Chain B Binding Site BS01

Receptor Information
>5nj7 Chain B (length=124) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHES
LADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTT
QANKHIIVACEGNPYVPVHFDASV
Ligand information
Ligand IDA6R
InChIInChI=1S/C4H8AsN2O4.Pt/c1-3(6)10-5(8,9)11-4(2)7;/h8-9H,1-2H3;/q-1;+1
InChIKeyOPINMBLEOXZNNE-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CC1=N[Pt]2N=C(C)O[As]2(O)(O)O1
OpenEye OEToolkits 2.0.6CC1=N[Pt]2N=C(O[As]2(O1)(O)O)C
FormulaC4 H8 As N2 O4 Pt
Namearsenoplatin-1
ChEMBL
DrugBank
ZINC
PDB chain5nj7 Chain B Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5nj7 Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		K7 Q11 V118 H119
Binding residue
(residue number reindexed from 1)		K7 Q11 V118 H119
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H12 K41 H119 F120 D121
Catalytic site (residue number reindexed from 1) H12 K41 H119 F120 D121
Enzyme Commision number 4.6.1.18: pancreatic ribonuclease.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity
GO:0004522 ribonuclease A activity
GO:0004540 RNA nuclease activity
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5nj7, PDBe:5nj7, PDBj:5nj7
PDBsum5nj7
PubMed30943017
UniProtP61823|RNAS1_BOVIN Ribonuclease pancreatic (Gene Name=RNASE1)

[Back to BioLiP]