Structure of PDB 5nig Chain B Binding Site BS01

Receptor Information

>5nig Chain B (length=197) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GDTRPRFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAV
TELGRPDAEYWNSQKDLLEQKRAAVDTYCRHNYGVGESFTVQRRVYPEVT
VYPAKTQPLQHHNLLVCSVNGFYPGSIEVRWFRNGQEEKTGVVSTGLIQN
GDWTFQTLVMLETVPRSGEVYTCQVEHPSLTSPLTVEWRASSADLVP

Ligand information

>5nig Chain C (length=15) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KRIAKAVNEKSCNCL

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5nig Memory T cells specific to citrullinated alpha-enolase are enriched in the rheumatic joint.
Resolution	1.35 Å
Binding residue (original residue number in PDB)	H13 Y30 D57 Y60 W61 L67 Y78 H81 N82 V85
Binding residue (residue number reindexed from 1)	H13 Y30 D57 Y60 W61 L67 Y78 H81 N82 V85

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0006955	immune response
GO:0019882	antigen processing and presentation

	Cellular Component
GO:0016020	membrane
GO:0042613	MHC class II protein complex

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Biological Process

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Cellular Component

External links

PDB	RCSB:5nig, PDBe:5nig, PDBj:5nig
PDBsum	5nig
PubMed	29853344
UniProt	P01911\|DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (Gene Name=HLA-DRB1)

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