Structure of PDB 5nd0 Chain B Binding Site BS01
Receptor Information
>5nd0 Chain B (length=109) Species:
9606
(Homo sapiens) [
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EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRK
IQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFAS
AMMHALEVL
Ligand information
>5nd0 Chain F (length=8) Species:
32630
(synthetic construct) [
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PPtTEDEL
Receptor-Ligand Complex Structure
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PDB
5nd0
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Resolution
1.45 Å
Binding residue
(original residue number in PDB)
Y16 K22 W23 K69 F77 Q79 R81 V86 N90
Binding residue
(residue number reindexed from 1)
Y14 K20 W21 K67 F75 Q77 R79 V84 N88
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:5nd0
,
PDBe:5nd0
,
PDBj:5nd0
PDBsum
5nd0
PubMed
33184177
UniProt
Q8N8S7
|ENAH_HUMAN Protein enabled homolog (Gene Name=ENAH)
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