Structure of PDB 5nc2 Chain B Binding Site BS01
Receptor Information
>5nc2 Chain B (length=109) Species:
9606
(Homo sapiens) [
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EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRK
IQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFAS
AMMHALEVL
Ligand information
>5nc2 Chain J (length=9) Species:
1639
(Listeria monocytogenes) [
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PPPPTEDEL
Receptor-Ligand Complex Structure
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PDB
5nc2
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Resolution
1.58 Å
Binding residue
(original residue number in PDB)
Y16 K22 W23 T30 N71 F77 Q79 R81 V86
Binding residue
(residue number reindexed from 1)
Y14 K20 W21 T28 N69 F75 Q77 R79 V84
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:5nc2
,
PDBe:5nc2
,
PDBj:5nc2
PDBsum
5nc2
PubMed
33184177
UniProt
Q8N8S7
|ENAH_HUMAN Protein enabled homolog (Gene Name=ENAH)
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