Structure of PDB 5n9d Chain B Binding Site BS01

Receptor Information
>5n9d Chain B (length=866) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGCNVSAPSGVLERVKELMEDYSRAPDAKFQQQFRHLLSVNFEEFVAETK
ERNADLDWVNPKLDERLQLELGQRQLEENAKKRLEARKKLPTMKYADDII
QAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCASSCRIICTQPRRI
SAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQQL
QSDPLMHNLSVLILDEIHERSVETDLLMGLLKVILPHRPDLKVILMSATV
REQDFCDYFNNCPMFRIEGVMFPVKMLYLEDVLSKTNYEFQKFRDRRPKR
DPPERRMKHEAMIEPYLRRIRNSYDSRVLDKLRLPESEGCEDIDFIADLV
YYICENEPEGAILVFLPGYDKISQLYNILDKPKTSKGQRWRDHMAVFPLH
SLMQSGEQQAVFRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKAT
NYDIETNIQSLDEVWVTKANTQQRRGRAGRVRPGICYNLFSRAREDRMDD
IPTPEILRSKLESIILSLKLLHIDDPYRFLQTLINAPNPEAIKMGVELLK
RIEALDQTGTLTPLGMHLAKLPIDPQMGKMILMSALFCCLDPITSAAAAL
SFKSPFYSPLGKESRVDEIKRRMARNMRSDHLMVHNTIIAYRDSRYSHAE
RDFCYKNFLSSMTLQQLERMKNQFSELLYNYKFLASSNCKDAASNKNSEK
IPLLRAIIGAGLYPNMAHLRKSRQIKNRVRAIHTMATDDGRRVNFHPSSV
NSGESGFDSAYFVYFQRQKSTDLFLLDSTMVFPMALIIFGDGVEAGVTQN
TPYLCVAKTYYFKCNRETADVVIQLRSNLEKLLLKKALYPAPIEENGYEK
QLIKAIELLLSLDERL
Ligand information
Receptor-Ligand Complex Structure
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PDB5n9d Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model.
Resolution2.71 Å
Binding residue
(original residue number in PDB)
R211 R212 Q237 R239 K244 T255 G257 V258 Q261 Q262 Q264 S265 G431 Y432 H463 S464 L465 T489 S495 K511 T513 L524 P635 I636 S664 D680 R793 H809 P810 S811 S833
Binding residue
(residue number reindexed from 1)
R148 R149 Q174 R176 K181 T192 G194 V195 Q198 Q199 Q201 S202 G368 Y369 H400 S401 L402 T426 S432 K448 T450 L461 P572 I573 S601 D617 R730 H746 P747 S748 S770
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0002151 G-quadruplex RNA binding
GO:0003676 nucleic acid binding
GO:0003678 DNA helicase activity
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0051880 G-quadruplex DNA binding
Biological Process
GO:0032508 DNA duplex unwinding
GO:0044806 G-quadruplex DNA unwinding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:5n9d, PDBe:5n9d, PDBj:5n9d
PDBsum5n9d
PubMed29429875
UniProtQ8SWT2

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