Structure of PDB 5n9a Chain B Binding Site BS01

Receptor Information
>5n9a Chain B (length=853) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IRLGCNVSAPSGVLERVKELMEDYSRAPDAKFQQQFRHLLSVNFEEFVAE
TKERNADLDWVNPKLDERLQLELGQRQLEENAKKRLEARKKLPTMKYADD
IIQAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCASSCRIICTQPR
RISAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQ
QLQSDPLMHNLSVLILDEIHERSVETDLLMGLLKVILPHRPDLKVILMSA
TVREQDFCDYFNNCPMFRIEGVMFPVKMLYLEDVLSKTNYEFQPPERRMK
HEAMIEPYLRRIRNSYDSRVLDKLRLPESEGCEDIDFIADLVYYICENEP
EGAILVFLPGYDKISQLYNILDKPKTSKGQRWRDHMAVFPLHSLMQSGEQ
QAVFRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKATNYDIETNI
QSLDEVWVTKANTQQRRGRAGRVRPGICYNLFSRAREDRMDDIPTPEILR
SKLESIILSLKLLHIDDPYRFLQTLINAPNPEAIKMGVELLKRIEALDQT
GTLTPLGMHLAKLPIDPQMGKMILMSALFCCLDPITSAAAALSFKSPFYS
PLGKESRVDEIKRRMARNMRSDHLMVHNTIIAYRDSRYSHAERDFCYKNF
LSSMTLQQLERMKNQFSELLYNYKFLASSNCKDAASNKNSEKIPLLRAII
GAGLYPNMAHLRKSRQRAIHTMATDDGRRVNFHPSSVNSGESGFDSAYFV
YFQRQKSTDLFLLDSTMVFPMALIIFGDGVEAGVTQNTPYLCVAKTYYFK
CNRETADVVIQLRSNLEKLLLKKALYPAPIEENGYEKQLIKAIELLLSLD
ERL
Ligand information
Receptor-Ligand Complex Structure
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PDB5n9a Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model.
Resolution3.036 Å
Binding residue
(original residue number in PDB)		R212 R239 T255 G257 V258 E286 G431 Y432 H463 S464 L465 T489 I491 K511 T513 P635 S664 D680 R793 H809 P810 S833 T834
Binding residue
(residue number reindexed from 1)		R151 R178 T194 G196 V197 E225 G360 Y361 H392 S393 L394 T418 I420 K440 T442 P564 S593 D609 R717 H733 P734 S757 T758
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0002151 G-quadruplex RNA binding
GO:0003676 nucleic acid binding
GO:0003678 DNA helicase activity
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0051880 G-quadruplex DNA binding
Biological Process
GO:0032508 DNA duplex unwinding
GO:0044806 G-quadruplex DNA unwinding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5n9a, PDBe:5n9a, PDBj:5n9a
PDBsum5n9a
PubMed29429875
UniProtQ8SWT2

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