Structure of PDB 5n96 Chain B Binding Site BS01

Receptor Information
>5n96 Chain B (length=851) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGCNVSAPSGVLERVKELMEDYSRAPDAKFQQQFRHLLSVNFEEFVAETK
ERNADLDWVNPKLDERLQLELGQRQLEENAKKRLEARKKLPTMKYADDII
QAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCASSCRIICTQPRRI
SAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQQL
QSDPLMHNLSVLILDEIHERSVETDLLMGLLKVILPHRPDLKVILMSATV
REQDFCDYFNNCPMFRIEGVMFPVKMLYLEDVLSKTNYEFQPPERRMKHE
AMIEPYLRRIRNSYDSRVLDKLRLPESEGCEDIDFIADLVYYICENEPEG
AILVFLPGYDKISQLYNILDKPKTSKGQRWRDHMAVFPLHSLMQSGEQQA
VFRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKATNYDIETNIQS
LDEVWVTKANTQQRRGRAGRVRPGICYNLFSRAREDRMDDIPTPEILRSK
LESIILSLKLLHIDDPYRFLQTLINAPNPEAIKMGVELLKRIEALDQTGT
LTPLGMHLAKLPIDPQMGKMILMSALFCCLDPITSAAAALSFKSPFYSPL
GKESRVDEIKRRMARNMRSDHLMVHNTIIAYRDSRYSHAERDFCYKNFLS
SMTLQQLERMKNQFSELLYNYKFLASSNCKDAASNKNSEKIPLLRAIIGA
GLYPNMAHLRKSRQRAIHTMATDDGRRVNFHPSSVNSGESGFDSAYFVYF
QRQKSTDLFLLDSTMVFPMALIIFGDGVEAGVTQNTPYLCVAKTYYFKCN
RETADVVIQLRSNLEKLLLKKALYPAPIEENGYEKQLIKAIELLLSLDER
L
Ligand information
Receptor-Ligand Complex Structure
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PDB5n96 Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model.
Resolution2.716 Å
Binding residue
(original residue number in PDB)		R211 R212 Q237 R239 T255 G257 V258 Q261 Q264 S265 G431 Y432 H463 S464 L465 T489 S495 K511 T513 P635 F665 D680 R793 H809 P810 S811 S833 T834
Binding residue
(residue number reindexed from 1)		R148 R149 Q174 R176 T192 G194 V195 Q198 Q201 S202 G358 Y359 H390 S391 L392 T416 S422 K438 T440 P562 F592 D607 R715 H731 P732 S733 S755 T756
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0002151 G-quadruplex RNA binding
GO:0003676 nucleic acid binding
GO:0003678 DNA helicase activity
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0051880 G-quadruplex DNA binding
Biological Process
GO:0032508 DNA duplex unwinding
GO:0044806 G-quadruplex DNA unwinding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5n96, PDBe:5n96, PDBj:5n96
PDBsum5n96
PubMed29429875
UniProtQ8SWT2

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