Structure of PDB 5n8r Chain B Binding Site BS01

Receptor Information
>5n8r Chain B (length=851) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGCNVSAPSGVLERVKELMEDYSRAPDAKFQQQFRHLLSVNFEEFVAETK
ERNADLDWVNPKLDERLQLELGQRQLEENAKKRLEARKKLPTMKYADDII
QAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCASSCRIICTQPRRI
SAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQQL
QSDPLMHNLSVLILDEIHERSVETDLLMGLLKVILPHRPDLKVILMSATV
REQDFCDYFNNCPMFRIEGVMFPVKMLYLEDVLSKTNYEFQPPERRMKHE
AMIEPYLRRIRNSYDSRVLDKLRLPESEGCEDIDFIADLVYYICENEPEG
AILVFLPGYDKISQLYNILDKPKTSKGQRWRDHMAVFPLHSLMQSGEQQA
VFRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKATNYDIETNIQS
LDEVWVTKANTQQRRGRAGRVRPGICYNLFSRAREDRMDDIPTPEILRSK
LESIILSLKLLHIDDPYRFLQTLINAPNPEAIKMGVELLKRIEALDQTGT
LTPLGMHLAKLPIDPQMGKMILMSALFCCLDPITSAAAALSFKSPFYSPL
GKESRVDEIKRRMARNMRSDHLMVHNTIIAYRDSRYSHAERDFCYKNFLS
SMTLQQLERMKNQFSELLYNYKFLASSNCKDAASNKNSEKIPLLRAIIGA
GLYPNMAHLRKSRQRAIHTMATDDGRRVNFHPSSVNSGESGFDSAYFVYF
QRQKSTDLFLLDSTMVFPMALIIFGDGVEAGVTQNTPYLCVAKTYYFKCN
RETADVVIQLRSNLEKLLLKKALYPAPIEENGYEKQLIKAIELLLSLDER
L
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5n8r Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		R211 R212 R239 T255 G257 Q261 Q262 Q264 S265 G431 Y432 S464 L465 T489 I491 S495 K511 T513 L524 E568 P635 I636 D680 R793 H809 P810 S833 T834 F837
Binding residue
(residue number reindexed from 1)		R148 R149 R176 T192 G194 Q198 Q199 Q201 S202 G358 Y359 S391 L392 T416 I418 S422 K438 T440 L451 E495 P562 I563 D607 R715 H731 P732 S755 T756 F759
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0002151 G-quadruplex RNA binding
GO:0003676 nucleic acid binding
GO:0003678 DNA helicase activity
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0051880 G-quadruplex DNA binding
Biological Process
GO:0032508 DNA duplex unwinding
GO:0044806 G-quadruplex DNA unwinding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5n8r, PDBe:5n8r, PDBj:5n8r
PDBsum5n8r
PubMed29429875
UniProtQ8SWT2

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