Structure of PDB 5mtz Chain B Binding Site BS01

Receptor Information
>5mtz Chain B (length=755) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FMFTFIPITHPTSDTKHPLLLVQSAHGEKYFFGKIGEGSQRSLTENKIRI
SKLKDIFLTGELNWSDIGGLPGMILTIADQGKSNLVLHYGNDILNYIVST
WRYFVFRFGIDLNDHIMKDKEVYKDKIIAVKSFNVLKNGGEDRLGVFDSF
QKGVLRSIVAKMFPKHAPTDRYDPSSDPHLNVELPDLDAKVEVSTNYEIS
FSPVRENERHFAKVLILDIPDDLYLNAFVEKFKDYDCAELGMVYYFLGDE
VTINDNLFAFIDIFEKNNYGKVNHMISHNKISPNTISFFGSALTTLKLKA
LQVNNYNLPKTDRVFSKDFYDRFDTPLSRGTSMCKSQEEPLNTIIEKDNI
HIFSQNKTVTFEPFRMNEEPMKCNINGEVADFSWQEIFEEHVKPLEFPLA
DVDTVINNQLHVDNFNNSAEKKKHVEIITLGTGSALPSKYRNVVSTLVKV
PFTDADGNTINRNIMLDAGENTLGTIHRMFSQLAVKSIFQDLKMIYLSHL
HADHHLGIISVLNEWYKYNKDDETSYIYVVTPWQYHKFVNEWLVLENKEI
LKRIKYISCEHFINDSFVRMQTQSVPLAEFNELELDRDSSYRDVDLIRQM
YEDLSIEYFQTCRAIHCDWAYSNSITFRMDENNEHNTFKVSYSGDTRPNI
EKFSLEIGYNSDLLIHEATLENQLLEDAVKKKHCTINEAIGVSNKMNARK
LILTHFSQRYPKLPQLDNNIDVMAREFCFAFDSMIVDYEKIGEQQRIFPL
LNKAF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5mtz Chain B Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5mtz The crystal structure of Trz1, the long form RNase Z from yeast.
Resolution2.99 Å
Binding residue
(original residue number in PDB)		H540 H542 H670 D699
Binding residue
(residue number reindexed from 1)		H499 H501 H616 D645
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.11: ribonuclease Z.
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0008270 zinc ion binding
GO:0042781 3'-tRNA processing endoribonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0008033 tRNA processing
GO:0042780 tRNA 3'-end processing
GO:1990180 mitochondrial tRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5mtz, PDBe:5mtz, PDBj:5mtz
PDBsum5mtz
PubMed28379452
UniProtP36159|RNZ_YEAST Ribonuclease Z (Gene Name=TRZ1)

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