Structure of PDB 5m3h Chain B Binding Site BS01

Receptor Information
>5m3h Chain B (length=750) Species: 11320 (Influenza A virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPMLIFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVIRTHDYS
SRGIWKTNSETGAQQLNPIDGPLPEDNEPSGYAQTDCVLELIEGLDRSHP
GLFETACQETIDAIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RKNGYKLNESGRLIDFLKDVLLSFENDSMEVTTHFQKKKRIRDNKKMITQ
RTIGKKRVKLTKKNYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFV
YFVELLARNICERLEQSGLPVGGNEKKAKLANVIKKMMAKSTDEELSYTI
TGDNTKWNENQNPRIFLAMVLRITAGQPEWFRDLLAVAPIMFSNKVARLG
RGYMFESKSMHLRTQISAENLSDINLRYFNEDTKKKIEKIRHLMVEGTAS
LSPGMMMGMFNMLSTVLGVSVLNLGQREILKRTYWWDGLQSSDDFALIIN
GHFKEDIQQGVNHFYRTCKLVGINMSQKKSYINKTGTFEFTSFFYRYGFV
ANFSMELPSFGVAGNNESADMSIGTTVIKTNMINNDLGPATAQMAIQLFI
KDYRYTYRCHRGDTNLETRRTKSIKRLWTETISKAGLLVADGGPNPYNLR
NLHIPEVCLKWSLMDPDYRGRLCNPNNPFVHHMEVESTNLAVVMPGPAKS
LEYDAVATTHSWTPKRNRSILNTNQRGILEDERIYQKCCQVFEKFFPSST
YRRPIGMASMLDAMLSRARIDARIDLESGRISSQDFSEITNTCKAIEALK
Ligand information
Receptor-Ligand Complex Structure
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PDB5m3h Structural basis of an essential interaction between influenza polymerase and Pol II CTD.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		N671 R672 S673 I674 N676
Binding residue
(residue number reindexed from 1)		N667 R668 S669 I670 N672
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5m3h, PDBe:5m3h, PDBj:5m3h
PDBsum5m3h
PubMed28002402
UniProtH6QM91

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