Structure of PDB 5ly2 Chain B Binding Site BS01
Receptor Information
>5ly2 Chain B (length=345) Species:
9606
(Homo sapiens) [
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PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASY
DDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTP
RYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDL
VEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWY
SVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDK
VTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCR
KDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL
Ligand information
>5ly2 Chain E (length=13) Species:
32630
(synthetic construct) [
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YVYNTKSGWRWYT
Receptor-Ligand Complex Structure
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PDB
5ly2
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Resolution
2.43 Å
Binding residue
(original residue number in PDB)
I87 Q88 K89 K90
Binding residue
(residue number reindexed from 1)
I78 Q79 K80 K81
Enzymatic activity
Catalytic site (original residue number in PDB)
G170 Y177 H188 E190 H276 S288
Catalytic site (residue number reindexed from 1)
G161 Y168 H179 E181 H267 S279
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69
: [histone H3]-trimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:5ly2
,
PDBe:5ly2
,
PDBj:5ly2
PDBsum
5ly2
PubMed
28382930
UniProt
O75164
|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)
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