Structure of PDB 5lxz Chain B Binding Site BS01

Receptor Information

>5lxz Chain B (length=601) Species: 457428 (Streptomyces lividans TK24)

AKINQPEYKAANGKWEIIEFPEKYRQNTIHAALLRTGKVLMVAGSGNNQD
NSDDKQYDTRIWDPVKGTIKKVPTPSDLFCTGHTQLANGNLLIAGGTKRY
EKLKGDVTKAGGLMVVHNENPDKPITLPAGTKFTGKENGKTFVSKDPVLV
PRAEKVFDGAFVRNDPGLGRIYVEAQKSGSAYETGTEDNYRVQGLSGADA
RNTYGIAQKLALDKKDFQGIRDAFEFDPVAEKYIKVDPMHEARAYPTLTT
LGDGKILSVSGLDDIGQLVPGKNEVYDPKTKAWTYTDKVRQFPTYPALFL
MQNGKIFYSGANAGYGPDDVGRTPGVWDVETNKFTKVPGMSDANMLETAN
TVLLPPAQDEKYMVIGGGGVGESKLSSEKTRIADLKADDPKFVDGPSLEK
GTRYPQASILPDDSVLVSGGSQDYRGRGDSNILQARLYHPDTNEFERVAD
PLVGRNYHSGSILLPDGRLMFFGSDSLYADKANTKPGKFEQRIEIYTPPY
LYRDSRPDLSGGPQTIARGGSGTFTSRAASTVKKVRLIRPSASTHVTDVD
QRSIALDFKADGDKLTVTVPSGKNLVQSGWYMMFVTDGEGTPSKAEWVRV
P

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 5lxz Chain B Residue 701

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5lxz The role of a second-coordination sphere tryptophan residue in the maturation of the catalytic metalloradical site in the auxillary activity family 5 (AA5) GlxA from Streptomyces lividans
• Resolution: 1.49 Å
• Binding residue (original residue number in PDB): Y289 Y501 H502 H589
• Binding residue (residue number reindexed from 1): Y245 Y457 H458 H545
• Annotation score: 3

Enzymatic activity

• Catalytic site (original residue number in PDB): Y289 D307 Y501 H502 H589
• Catalytic site (residue number reindexed from 1): Y245 D263 Y457 H458 H545

Gene Ontology

Molecular Function

• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process

External links

• PDB: RCSB:5lxz, PDBe:5lxz, PDBj:5lxz
• PDBsum: 5lxz
• UniProt: D6EWM0