Structure of PDB 5lrn Chain B Binding Site BS01

Receptor Information
>5lrn Chain B (length=325) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPTIYHAKDAVQATKPDMRKPRLVVFVVGETARADHVSFNGYERDTFPQL
AKIDGVTNFSNVTSCGTSTAYSVPCMFSYLGADEYDVDTAKYQENVLDTL
DRLGVSILWRDNNSDSKGVMDKLPKAQFADYKSATNNAICNTNPYNECRD
VGMLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFTPVCEG
NELAKCEHQSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDH
GESLGENGVYLHGMPNAFAPKEQRSVPAFFWTDKQTGITPMATDTVLTHD
AITPTLLKLFDVTADKVKDRTAFIR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5lrn Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5lrn Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		E246 T285 D465 H466
Binding residue
(residue number reindexed from 1)		E30 T69 D249 H250
Annotation score4
Enzymatic activity
Enzyme Commision number 2.7.-.-
Gene Ontology
Molecular Function
GO:0016772 transferase activity, transferring phosphorus-containing groups

View graph for
Molecular Function
External links
PDB RCSB:5lrn, PDBe:5lrn, PDBj:5lrn
PDBsum5lrn
PubMed28059088
UniProtA0A0R6L508|MCR1_ECOLX Probable phosphatidylethanolamine transferase Mcr-1 (Gene Name=mcr1)

[Back to BioLiP]