Structure of PDB 5lgr Chain B Binding Site BS01

Receptor Information
>5lgr Chain B (length=343) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDF
KDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTD
RIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSG
NMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDE
YFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGL
VHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDT
LSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5lgr Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Q149 F153 Y154 N162 E258 M260 Y262 E267 K310 Q338 H415 Y417 N472 Y477
Binding residue
(residue number reindexed from 1)		Q15 F19 Y20 N28 E124 M126 Y128 E133 K176 Q204 H281 Y283 N338 Y343
Enzymatic activity
Catalytic site (original residue number in PDB) D166 E258 E267 H415
Catalytic site (residue number reindexed from 1) D32 E124 E133 H281
Enzyme Commision number 2.1.1.319: type I protein arginine methyltransferase.
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5lgr, PDBe:5lgr, PDBj:5lgr
PDBsum5lgr
PubMed28330993
UniProtQ9WVG6|CARM1_MOUSE Histone-arginine methyltransferase CARM1 (Gene Name=Carm1)

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