Structure of PDB 5l1z Chain B Binding Site BS01

Receptor Information
>5l1z Chain B (length=255) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQ
LTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIK
VAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTH
VVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACK
WSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIW
NWRAC
Ligand information
>5l1z Chain N (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugagccugggagcucuc
.....<<<<......>>>>..
Receptor-Ligand Complex Structure
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PDB5l1z Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.
Resolution5.9 Å
Binding residue
(original residue number in PDB)		R259 C261
Binding residue
(residue number reindexed from 1)		R253 C255
Binding affinityPDBbind-CN: Kd=0.20nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:5l1z, PDBe:5l1z, PDBj:5l1z
PDBsum5l1z
PubMed27731797
UniProtO60563|CCNT1_HUMAN Cyclin-T1 (Gene Name=CCNT1)

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