Structure of PDB 5kzm Chain B Binding Site BS01

Receptor Information

>5kzm Chain B (length=395) Species: 177416 (Francisella tularensis subsp. tularensis SCHU S4)

MSKLNAYFGEYGGQFVPQILVPALDQLEQEFIKAQADESFKQEFKELLQE
YAGRPTALTKTRNIVKNTRTKLYLKREDLLHGGAHKTNQVLGQALLAKRM
GKKEIIAETGAGQHGVATALACALLDLKCRVYMGAKDVERQSPNVFRMKL
MGAEVIPVHSGSATLKDACNEALRDWSANYSKAHYLLGTAAGPHPFPTIV
REFQRMIGEETKQQMLAKEGRLPDAVIACVGGGSNAIGMFADFIDEKNVK
LIGVEPAGKGIETGEHGAPLKHGKTGIFFGMKAPLMQNSDGQIEESYSIS
AGLDFPSVGPQHAHLLAIGRAKYASATDDEALDAFKLLCKKEGIIPALES
SHALAHALKLAYEDPNKEQLLVVNLSGRGDKDIFTVHDILKEKGE

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 5kzm Chain B Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5kzm Conservation of the structure and function of bacterial tryptophan synthases.
• Resolution: 2.804 Å
• Binding residue (original residue number in PDB): E295 S296 D304
• Binding residue (residue number reindexed from 1): E295 S296 D304
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): K86 E108 S376
• Catalytic site (residue number reindexed from 1): K86 E108 S376
• Enzyme Commision number: 4.2.1.20: tryptophan synthase.

Gene Ontology

Molecular Function

• GO:0004834 tryptophan synthase activity
• GO:0016829 lyase activity

Biological Process

• GO:0000162 tryptophan biosynthetic process
• GO:0006568 tryptophan metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5kzm, PDBe:5kzm, PDBj:5kzm
• PDBsum: 5kzm
• PubMed: 31316809
• UniProt: Q5NE79|TRPB_FRATT Tryptophan synthase beta chain (Gene Name=trpB)