Structure of PDB 5kdx Chain B Binding Site BS01

Receptor Information
>5kdx Chain B (length=883) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATQEEILDAALVSGDSSQLTDSHLVALRLQQQVERIRQTRTQLLDGLYQN
LSQAYDPGAASMWVLPANPDNTLPFLIGDKGRVLASLSLEAGGRGLAYGT
NVLTQLSGTNAAHAPLLKRAVQWLVNGDPGAATAKDFKVSVVGVDKTAAL
NGLKSAGLQPADAACNALTDASCASTSKLLVLGNGASAASLSATVRARLQ
AGLPILFVHTNGWNQSSTGQQILAGLGLQEGPYGGNYWDKDRVPSSRTRT
RSVELGGAYGQDPALVQQIVDGSWRTDYDWSKCTSYVGRTTCDDVPGLSD
FSKRVDVLKGALDAYNQKAQNLFALPGTTSLRLWLLWADAVRQNIRYPMD
KAADTARFQETFVADAIVGYVREAGAAQKELGSYAGQRQQSMPVSGSEET
LTLTLPSAQGFTAIGRMAAPGKRLSIRIEDAGQASLAVGLNTQRIGSTRL
WNTRQYDRPRFLKSPDIKLQANQSVALVSPYGGLLQLVYSGATPGQTVTV
KVTGAASQPFLDIQPGEDSSQAIADFIQALDADKADWLEIRSGSVEVHAK
VEKVRGSIDKDYGGDVQRFIRELNEVFIDDAYTLAGFAIPNQAKTPAIQQ
ECAARGWDCDSETLHKLPGTQHINVDQYAQCGGGCSGNPYDQTWGLNPRG
WGESHELGHNLQVNRLKVYGGRSGEISNQIFPLHKDWRVLREFGQNLDDT
RVNYRNAYNLIVAGRAEADPLAGVYKRLWEDPGTYALNGERMAFYTQWVH
YWADLKNDPLQGWDIWTLLYLHQRQVDKSDWDANKAALGYGTYAQRPGNS
GDASSTDGNDNLLLGLSWLTQRDQRPTFALWGIRTSAAAQAQVAAYGFAE
QPAFFYANNRTNEYSTVKLLDMSQGSPAWPFPL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5kdx Chain B Residue 1006 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5kdx Recognition of protein-linked glycans as a determinant of peptidase activity.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		H696 H700 E716
Binding residue
(residue number reindexed from 1)		H655 H659 E675
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.-
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0015628 protein secretion by the type II secretion system
GO:0030163 protein catabolic process
GO:0043952 protein transport by the Sec complex
GO:1903237 negative regulation of leukocyte tethering or rolling
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5kdx, PDBe:5kdx, PDBj:5kdx
PDBsum5kdx
PubMed28096352
UniProtQ9I5W4|IMPA_PSEAE Immunomodulating metalloprotease (Gene Name=impA)

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