Structure of PDB 5k0k Chain B Binding Site BS01

Receptor Information

>5k0k Chain B (length=248) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LEDVVIDRNLLILGKILGEGGSVMEGNLKQEDGTSLKVAVKTEAACMKDF
SHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKH
IPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFPV
KWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLL
HGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLP

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

5k0k Chain B Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	5k0k Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors.
Resolution	2.545 Å
Binding residue (original residue number in PDB)	N728 D741
Binding residue (residue number reindexed from 1)	N134 D147
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	D723 A725 R727 N728 D741
Catalytic site (residue number reindexed from 1)	D129 A131 R133 N134 D147
Enzyme Commision number	2.7.10.1: receptor protein-tyrosine kinase.

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:5k0k, PDBe:5k0k, PDBj:5k0k
PDBsum	5k0k
PubMed	27994735
UniProt	Q12866\|MERTK_HUMAN Tyrosine-protein kinase Mer (Gene Name=MERTK)

[Back to BioLiP]