Structure of PDB 5jmo Chain B Binding Site BS01

Receptor Information
>5jmo Chain B (length=471) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIE
KNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVAN
NGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPE
DDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDG
YTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLR
QKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLN
ANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTE
PKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVS
PMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEA
NNYGTLTKFTLVLYGTASGSL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5jmo The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
Resolution1.998 Å
Binding residue
(original residue number in PDB)		D154 H194 E236 S253 W254 G255 E257 D258 D264 G294 N295 D306 Y308 S368
Binding residue
(residue number reindexed from 1)		D47 H87 E129 S146 W147 G148 E150 D151 D157 G187 N188 D199 Y201 S261
Enzymatic activity
Catalytic site (original residue number in PDB) S150 D191
Catalytic site (residue number reindexed from 1) S43 D84
Enzyme Commision number 3.4.21.75: furin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5jmo, PDBe:5jmo, PDBj:5jmo
PDBsum5jmo
PubMed27670069
UniProtP09958|FURIN_HUMAN Furin (Gene Name=FURIN)

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