Structure of PDB 5jhq Chain B Binding Site BS01

Receptor Information

>5jhq Chain B (length=461) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDV
VEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNW
NYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLT
GEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNR
VRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAM
DLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELR
ERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVA
SLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG
AKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMG
NEAVQQILSES

Ligand information

>5jhq Chain G (length=11) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

YRQSPDGACSV

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5jhq Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	R215 F222 G225 F226 L250 N255 S258 F259 H261 D279 W281 Y283 E288
Binding residue (residue number reindexed from 1)	R34 F41 G44 F45 L69 N74 S77 F78 H80 D98 W100 Y102 E107

Enzymatic activity

Enzyme Commision number

2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.

External links

PDB	RCSB:5jhq, PDBe:5jhq, PDBj:5jhq
PDBsum	5jhq
PubMed	27594684
UniProt	O95271\|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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