Structure of PDB 5jft Chain B Binding Site BS01

Receptor Information
>5jft Chain B (length=235) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AFRYSLNYPNIGHCIIINNKNFDRRTGMNPRNGTDVDAGNVMNVFRKLGY
IVKVYNDQTVAQIMQVLTTVAHDDHSRCASLVCVLLSHGDEGVFFGTDTS
VDLKSLTSLFRGDRCPSLVGKPKLFFIQACRGTELDPGVETRERIPVEAD
FLYAYSTVPGYYSWRNTMTGSWFIQSLCEMMTKYGSELELLQIMTRVNHK
VALDFESTSNMPGFDAKKQIPCIVSMLTKEMYFTP
Ligand information
>5jft Chain C (length=4) Species: 142878 (unidentified 'CNM-group' bacterium HXN600) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DEVD
Receptor-Ligand Complex Structure
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PDB5jft Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish.
Resolution2.28 Å
Binding residue
(original residue number in PDB)		R67 Q164 C166 Y209 S210 W211 R212 N213 T214 S254
Binding residue
(residue number reindexed from 1)		R31 Q128 C130 Y162 S163 W164 R165 N166 T167 S207
Enzymatic activity
Catalytic site (original residue number in PDB) N65 P66 H124 G125 C166 R167
Catalytic site (residue number reindexed from 1) N29 P30 H88 G89 C130 R131
Enzyme Commision number 3.4.22.56: caspase-3.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5jft, PDBe:5jft, PDBj:5jft
PDBsum5jft
PubMed27577093
UniProtA0A2R8QUC0

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